What Science says

Indeed is not intended to provide the reader with highly censored information (www.PuMed freely available) related to the ongoing basic and clinical research regarding food supplements containing antioxidants in particular lycopene.

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Because of the high content in lycopene and other healthy micronutrients, a constant consumption of tomato products has been associated with reduction of risk factors such as high blood levels of LDL colesterol , metabolic syndrome associated with cardiovascular diseases

Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases-A Critical Review. Müller L et al. CritTev Food SciNutr ( 2016) 56,1868-79

The Lycocard European Project Lycopene and Cardiovascular Diseases
Böhm, V. Institute of Nutrition, Friedrich Schiller University Jena, Germany

Intake of cooked tomato sauce preserves coronary endothelial function and improves apolipoprotein A-I and apolipoprotein J protein profile in high-density lipoprotein. Vilahur G et al Transl Res ( 2015) 166:44-56

The Mediterranea Diet which provides high levels of antioxidants, expecially lycopene and polyphenols may help to maintain an healthy prostate in a dose dependent manner.
Lycopene has been reported to decrease the risk of cardiovascular ailment and the osteporosis associate with the androgen deprivation therapy.

Dietary Total Antioxidant Capacity is Inversely Associated with Prostate Cancer Aggressiveness in a Population-Based Study. Vance TM et al. Nutr Cancer. (2016) 68 (2), 214-24

Prevalence of Cardiovascular Disease and Osteoporosis During Androgen Deprivation Therapy Prescription Discordant to EAU Guidelines: Results From a Multicenter, Cross-sectional Analysis From the CHOsIng Treatment for Prostate canCEr (CHOICE) Study Morgia G et al Urology 2016 Oct;96:165-170. doi: 10.1016/j Urology (2016) 06.024. Epub 2016 Jul 8.

Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.
Nordström T et al Prostate (2015) 9 Nov 20. doi: 10.1002/pros.23125

Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. PLoS One ( 2015) 10(9) doi: 10.1371/journal.pone.0137427

Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial Vanessa Er et al
Cancer Epidemiol Biomarkers Prev (2015) 23(10), 2066–77

Il Licopene, nella forma altamente assorbibile del Lycoprozen, può vantaggiosamente essere associato a preparati con Serenoa Repens nel trattamento delle disfunzioni prostatiche la cui incidenza va aumentando al di sotto dei 50 anni

Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study Morgia G et al Int J Mol Sci (2017) 18(3). pii: E680. doi: 10.3390/ijms18030680

Inhibitors of apoptosis proteins in experimental benign prostatic hyperplasia: effects of serenoa repens, selenium and lycopene Minutoli L et al J Biomed Sci (2014) Mar 10;21:19. doi: 10.1186/1423-0127-21-19.

Effect of Serenoa Repens, Lycopene, and selenium on proinflammatori phenotype activation: an in vitro and in vivo comparison study Bonvissuto et al Urology (2011) 77:248.e9-16

Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus selenium and lycopene (Profluss) versus S. repens alone: an Italian randomized multicenter-controlled study. Morgia G et al Urol Int (2010) 84:400-6

The noxious activity of free radicals at vascular , metabolic and cerebral level is significantly responsible for the aging related mental decay . Because of its antioxidant activity and content in neuroprotective minerals , Lycoprozen® can contrast the effect of free radicals at vascular and cerebral level as well.

Dementia prevention, intervention, and care Livingston G et al Lancet (2017) 390, 2673–734
Olive polyphenols: new promising agents to combat aging-associate neurodegeneration. Casamenti F, Stefani M Expert Rev Neurother ( 2017) 4,345-358

Pantano D et al Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology Br J Clin Pharmacol (2017) 83, 54–62

Plasma Carotenoids Are Inversely Associated with Dementia Risk in an Elderly French Cohort. Feart C et al J Gerontol A Biol Sci Med Sci Gerontol A J Biol Sci Med Sci (2016) 71(5), 683-8

A randomised controlled intervention trial evaluating the efficacy of a Mediterranean dietary pattern on cognitive function and psychological wellbeing in healthy older adults: the MedLey study.Knight A et al BMC Geriatr. (2015) 28,15:55

Dietary patterns, cognitive decline, and dementia: a systematic review. van de Rest O et al. Adv Nutr. (2015) 16,154-68

Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats.Yin Q et al Neuropharmacology. (2014) 86,389-96

Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer’s disease mortality in older adults. Min JY and Min KB. Dement Geriatr Cogn Disord (2014) 37,246-56

Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease. Rinaldi P et al Neurobiol Aging (2003) 24: 915-9

An inverse relationship between lycopene blood levels and bone fragility (hip fracture) has been reported , thus lycopene dietary supplementation can contrast those various risk factors associated with bone fragility.

Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Mackinnon ES et al. J Nutr Health Aging ( 2011) 22,1091-101

Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. Sahni S et al J Bone Miner Res (2009) 24,1086-94

Because Lycopene is one of the dietary micronutrient which concentrates in the eye. This carotenoid has been reported to be beneficial in some age related degenerative ocular diseases

Antioxidant Treatment Limits Neuroinflammation in Experimental Glaucoma. Yang Xm et al Invest Ophthalmol Vis Sci (2016) 57(4): 2344-54

Serum carotenoids and risk of age-related macular degeneration in a Chinese population sample.Zhou H et al. Invest Ophthalmol Vis Sci (2011) 52: 338-4

Plasma carotenoids and diabetic retinopathy. Brazionis L et al Br J Nutr (2009) Jan;101(2):270-7
Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year. Parisi V et al CARMIS Study Group. (2008) Feb;115 (2):324-333.e2.

Lycopene but not lutein nor zeaxanthin decreases in serum and lipoproteins in age-related macular degeneration patients.Cardinault N et al Clin Chim Acta (2005) 357(1):34-42.

Serum oxidative and antioxidant parameters in a group of Italian patients with age-related maculopathy. Simonelli F et al Clin Chim Acta (2002) 320 (1-2):111-5.

Because lycopene has been reported to be exert anti inflammatory activity, to lower LDL colesterol and increase sensitivity to insulin, the uptake of this carotenoid under medical advice can lower the risks associated with elevated BMI and metabolic syndrome and to maintain the prostate health.

Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders. Fenni S et al Mol Nutr Food Res (2017) 61 (9). doi: 10.1002/mnfr.201601083.

Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome. Han GM et al. Nutr Res ( 2016) 36, 402-7

Dietary supplementation with tomato-juice in patients with metabolic syndrome: a suggestion to alleviate detrimental clinical factors.Tsitsimpikou C et al Food Chem Toxicol (2014) 74:9-13

In view that protection from UV and blue light radiation can be optimally reached by providing external and internal protection (Total Protection), the latter type of shielding can be potentially achieved by circulating antioxidants,including lycopene

Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study. Grether-Beck S et al Br J Dermatol (2017) 176(5),1231-1240. doi: 10.1111/bjd.15080

Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms. Lephart ED Ageing Res Rev ( 2016) doi:10.1016/j.arr.2016.08.001

Attività biologica del licopene e prospettive d’impiego in dermatologia. Cazzola P Journal of Plastic Dermatology ( 2012) 8,199-210.

Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation.
McDaniel DH et al J of Drugs in Dermatology (2015) vol.14 Suppl. 7

Radio and chemotherapies are known to be associated with the excess production of free radicals responsible for the onset of a number of side effects ( cardiac, renal, pulmonary, neurologic). In this context, the uptake of extra amount of lycopene, when compatible with the adopted therapeutic regimens can contribute to alleviate the side effects.

Phytochemicals as adjunctive with conventional anticancer therapies, Farzaei MH et al. Curr Pharm Des. (2016) 22:4221-18

In view that lycopene body concentration riches high levels in testis and seminal fluid, dietary supplementation of carotenoid has been recommended in case of male infentility of unkown origin.

A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Mendiola J et a Fertil Steril. (2010) 93(4):1128-33

Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. Benedetti S, et al Reprod Biomed Online. (2012) 25(3):300-6

Medical management of male infertility in the absence of a specific etiology.Gudeloglu A et al Semin Reprod Med (2014) 32(4):313-8

Being a fraction of these processes linked to common systemic diseases such diabetes, the uptake of food supplements containing micronutrients which provide anti inflammatory activity and help to regulate the sugars metabolism is receiving increasing interest.

Evaluation of oxidative stress in chronic periodontitis patients following systemic antioxidant supplementation: A clinical and biochemical study.Ambati M et al J Nat Sci Biol Med. (2017) Jan-Jun;8(1):99-103. doi: 10.4103/0976-9668.198366

Systemic lycopene as an adjunct to scaling and root planing in chronic periodontitis patients with type 2 diabetes mellitus Reddy PV et al J Int Soc Prev Community Dent 2015 May;5(Suppl 1):S25-31. doi: 10.4103/2231-0762.156520.

What it contains

The whole (skin and seeds) ripe tomato represents the main dietary source of lycopene a natural dye belonging to the family of antioxidant called carotenoids. The absoption of this molecule is increased by cooking the fruit and in presence of fats and other antioxidants (polyphenols) expecially those of olives. Its biological activity is optimized in presence of other micronutrients present in the fruit and produced after cooking.

Rowles JL et al. Processed and raw tomato consumption and risk of prostate cancer: a systematic review and dose-response meta-analysis.Prostate Cancer Prostatic Dis 2018 (9 gennaio) (Epub ahead of print)

Tomato (Solanum lycopersicum) Carotenoids and Lycopenes Chemistry; Metabolism, Absorption, Nutrition, and Allied Health Claims–A Comprehensive Review. Perveen R et al Crit Rev Food Sci Nutr (2015) 55(7):919-29

Enhancing the Health-Promoting Effects of Tomato Fruit for Biofortified Food Raiola A et al Mediators of Inflammation (2014) doi:10.1155/2014/139873. Review

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials. Basu1 A and Imrhan V European Journal of Clinical Nutrition (2007) 61, 295–303

Olive vegetation water is a waste portion of olive mills which contains high concentration of polyphenols (tyrosol, idrossityrosol, oleopeurin) the only source being the diet. As lycopene, they posses high antioxidant activity which may contribute to conteract the effect of free radicals and to protect carotenoids from oxidation.

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology Pantano D et al Br J Clin Pharmacol (2017) 83, 54–62

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health
Barbara Barbaro et al
Int. J. Mol. Sci. (2014) 15, 18508-18524

Polyphenols and human health: a prospectus. Visioli F et al Crit Rev Food Sci Nutr (2011) 6, 24-46

Hydrolyzed Olive Vegetation Water in Mice Has Anti-Inflammatory Activity1 Catherine M. Bitler,2 Tiffany M. Viale, Bassam Damaj,* and Roberto Crea
J. Nutr. (2005) 135: 1475–1479

When uptaken as salt of pyruvic acid is a key element for the sugars metabolism from which nervous cells are higly depenent on.

A unique array of neuroprotective effects of Pyruvate in neuropathology. Zilberter Y, Gubkina O and Ivanov AI Front. Neurosci. 9:17. doi:10.3389/fnins.2015.00017, (2015)

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer’s disease without reducing amyloid and tau pathology Isopi E. et al. Neurobiol Dis. (2015) Sep;81:214-24. doi: 10.1016/j.nbd.2014.11.013

Innate immune activation in neurodegenerative disease. Heneka MT et al Nat Rev Immunol (2014) 14, 463-477

Metabolic dysfunction in Alzheimer’s disease and related neurodegenerative disorders. Cai H et al Curr Alzheimer Res ( 2012) 9, 5-17

Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives. . Melo, A et al. Oxid Med Cell Longev (2011) 467180.

Magnesium is a key compound in generating energy from the metabolism of proteins, fats and sugars, thus being highly revelant for the functioning of the nervous system.

Effects of nutrient and bioactive food components on Alzheimer’s disease and epigenetic. Crit Rev Food Sci Nutr. 2017 Aug 11:1-12. doi: 10.1080/10408398.2017.1359488. [Epub ahead of print]

Serum magnesium is associated with the risk of dementia.
Kieboom BCT et al Neurology.( 2017) 89(16),1716-1722

Magnesium Status in Alzheimer’s Disease: A Systematic Review Veronese N et al Am J Alzheimers Dis Other Demen (2016) 3,208-13

Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer’s model Xu ZP det al PLoS One (2014) doi: 10.1371/journal.pone.0108645

Higher dietary intakes of potassium, calcium and magnesium are associated with a reduced risk of developing vascular dementia. Cherbuin N. Evid Based Ment Health. (2013) 1:26. doi: 10.1136/eb-2012-101043

Togheter with Iron, is indipensable in a variety of enzymatic processes which modulate cell respiration, oxidative stress and DNA repair. Vegetables are the main dietaray source. Its antioxidant activity decreases the unhealthy effects of free radicals also in the brain.

Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper. Sandusky-Beltran LA et al Behav Brain Res.(2017) 333:179-183

Zinc and the aging brain. Nuttall JR , Oteiza PI. Genes Nutr (2014) 9:379.

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction Corona C et al Cell Death and Disease (2010) 1, e91; doi:10.1038/cddis.2010.73

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